MHCI Weekly Benchmark results
Overall scores
Overall scores based on data sets submitted to the IED for the last at least 5 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.
Server | Overall | SRCC | AUC |
---|---|---|---|
ANN 3.4 | 48 | 48 | 49 |
ANN 4.0 | 69 | 70 | 69 |
ARB | 21 | 21 | 20 |
IEDB Consensus | 58 | 53 | 63 |
NetMHCcons | 63 | 58 | 69 |
NetMHCpan 2.8 | 60 | 61 | 60 |
NetMHCpan 3.0 | 59 | 60 | 59 |
NetMHCpan 4.0 BA | - | - | - |
NetMHCpan 4.0 EL | - | - | - |
NetMHCpan 4.1 BA | - | - | - |
NetMHCpan 4.1 EL | - | - | - |
PickPocket | 42 | 41 | 42 |
SMM | 40 | 39 | 41 |
SMMPMBEC | 41 | 40 | 43 |
mhcflurry 1.2.0 | 85 | 87 | 84 |
Data set specific results
Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here
Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.
IEDB Reference |
Allele | Peptide Length |
Peptide Count |
Positive Count |
Measurement type |
ANN 3.4 | ANN 4.0 | ARB | IEDB Consensus | NetMHCcons | NetMHCpan 2.8 | NetMHCpan 3.0 | NetMHCpan 4.0 BA | NetMHCpan 4.0 EL | NetMHCpan 4.1 BA | NetMHCpan 4.1 EL | PickPocket | SMM | SMMPMBEC | mhcflurry 1.2.0 | |||||||||||||||
SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | ||||||
1026371 | HLA-A*02:01 | 9 | 85 | 49 | t1/2 | 0.576 | 0.819 | 0.574 | 0.814 | 0.563 | 0.811 | 0.521 | 0.802 | 0.571 | 0.819 | 0.559 | 0.812 | 0.569 | 0.811 | - | - | - | - | - | - | - | - | 0.540 | 0.794 | 0.557 | 0.811 | 0.557 | 0.812 | 0.599 | 0.816 |
1026371 | HLA-A*02:01 | 10 | 22 | 12 | t1/2 | 0.191 | 0.583 | 0.064 | 0.517 | 0.106 | 0.533 | 0.127 | 0.567 | 0.147 | 0.558 | 0.152 | 0.567 | 0.122 | 0.542 | - | - | - | - | - | - | - | - | 0.074 | 0.558 | 0.144 | 0.558 | 0.110 | 0.550 | 0.165 | 0.583 |
1026371 | HLA-B*07:02 | 9 | 43 | 17 | t1/2 | 0.839 | 0.964 | 0.825 | 0.943 | 0.529 | 0.783 | 0.792 | 0.962 | 0.840 | 0.950 | 0.858 | 0.952 | 0.864 | 0.973 | - | - | - | - | - | - | - | - | 0.650 | 0.879 | 0.790 | 0.959 | 0.806 | 0.959 | 0.845 | 0.959 |
1026371 | HLA-B*07:02 | 10 | 25 | 9 | t1/2 | 0.583 | 0.736 | 0.708 | 0.819 | 0.568 | 0.715 | 0.596 | 0.736 | 0.622 | 0.757 | 0.663 | 0.785 | 0.623 | 0.771 | - | - | - | - | - | - | - | - | 0.594 | 0.729 | 0.577 | 0.729 | 0.608 | 0.729 | 0.666 | 0.778 |
1026840 | HLA-A*02:01 | 9 | 357 | 76 | binary | 0.547 | 0.886 | 0.575 | 0.906 | 0.564 | 0.898 | 0.582 | 0.914 | 0.571 | 0.907 | 0.576 | 0.906 | 0.574 | 0.905 | - | - | - | - | - | - | - | - | 0.553 | 0.890 | 0.568 | 0.900 | 0.567 | 0.900 | 0.580 | 0.909 |
1026840 | HLA-A*02:01 | 9 | 24 | 14 | ic50 | 0.265 | 0.593 | 0.330 | 0.636 | 0.402 | 0.693 | 0.187 | 0.561 | 0.321 | 0.650 | 0.340 | 0.671 | 0.375 | 0.664 | - | - | - | - | - | - | - | - | 0.381 | 0.679 | 0.327 | 0.636 | 0.287 | 0.614 | 0.467 | 0.714 |
1026840 | HLA-A*02:01 | 9 | 24 | 7 | t1/2 | 0.321 | 0.689 | 0.411 | 0.765 | 0.447 | 0.706 | 0.279 | 0.706 | 0.402 | 0.723 | 0.439 | 0.739 | 0.479 | 0.756 | - | - | - | - | - | - | - | - | 0.387 | 0.672 | 0.382 | 0.748 | 0.350 | 0.731 | 0.479 | 0.748 |
1026840 | HLA-A*24:02 | 9 | 357 | 49 | binary | 0.438 | 0.868 | 0.431 | 0.861 | 0.404 | 0.836 | 0.421 | 0.859 | 0.444 | 0.880 | 0.444 | 0.873 | 0.434 | 0.864 | - | - | - | - | - | - | - | - | 0.409 | 0.846 | 0.405 | 0.839 | 0.401 | 0.837 | 0.428 | 0.859 |
1026840 | HLA-A*24:02 | 9 | 20 | 12 | ic50 | 0.209 | 0.635 | 0.229 | 0.646 | 0.046 | 0.500 | 0.368 | 0.760 | 0.200 | 0.656 | 0.209 | 0.667 | 0.296 | 0.729 | - | - | - | - | - | - | - | - | 0.450 | 0.802 | 0.400 | 0.771 | 0.381 | 0.781 | 0.390 | 0.792 |
1026840 | HLA-A*30:01 | 9 | 349 | 8 | binary | 0.141 | 0.771 | 0.169 | 0.825 | 0.108 | 0.708 | 0.122 | 0.786 | 0.152 | 0.816 | 0.160 | 0.809 | 0.157 | 0.802 | - | - | - | - | - | - | - | - | 0.127 | 0.765 | 0.151 | 0.791 | 0.147 | 0.824 | 0.214 | 0.912 |
1026840 | HLA-A*30:02 | 9 | 360 | 109 | binary | 0.403 | 0.753 | 0.396 | 0.749 | 0.249 | 0.661 | 0.399 | 0.753 | 0.435 | 0.775 | 0.425 | 0.767 | 0.447 | 0.781 | - | - | - | - | - | - | - | - | 0.403 | 0.756 | 0.361 | 0.728 | 0.346 | 0.718 | 0.518 | 0.826 |
1026840 | HLA-A*30:02 | 9 | 56 | 35 | ic50 | 0.134 | 0.601 | 0.030 | 0.536 | 0.269 | 0.661 | 0.078 | 0.567 | 0.045 | 0.529 | 0.011 | 0.483 | -0.019 | 0.494 | - | - | - | - | - | - | - | - | -0.101 | 0.419 | 0.121 | 0.569 | 0.075 | 0.550 | 0.581 | 0.792 |
1026840 | HLA-A*30:02 | 9 | 56 | 14 | t1/2 | 0.185 | 0.554 | 0.075 | 0.485 | 0.152 | 0.523 | 0.070 | 0.486 | 0.091 | 0.504 | 0.053 | 0.503 | 0.033 | 0.485 | - | - | - | - | - | - | - | - | -0.013 | 0.467 | 0.065 | 0.502 | 0.118 | 0.532 | 0.189 | 0.571 |
1026840 | HLA-A*68:01 | 9 | 436 | 43 | binary | 0.383 | 0.871 | 0.399 | 0.886 | 0.336 | 0.791 | 0.388 | 0.883 | 0.387 | 0.884 | 0.385 | 0.873 | 0.368 | 0.856 | - | - | - | - | - | - | - | - | 0.396 | 0.889 | 0.374 | 0.863 | 0.390 | 0.878 | 0.390 | 0.877 |
1026840 | HLA-A*68:01 | 9 | 35 | 13 | ic50 | 0.651 | 0.843 | 0.680 | 0.850 | 0.526 | 0.774 | 0.657 | 0.823 | 0.646 | 0.850 | 0.631 | 0.843 | 0.601 | 0.843 | - | - | - | - | - | - | - | - | 0.637 | 0.857 | 0.625 | 0.794 | 0.634 | 0.832 | 0.708 | 0.871 |
1026840 | HLA-A*68:01 | 9 | 35 | 19 | t1/2 | -0.407 | 0.266 | -0.398 | 0.283 | -0.385 | 0.308 | -0.422 | 0.265 | -0.353 | 0.293 | -0.316 | 0.322 | -0.199 | 0.385 | - | - | - | - | - | - | - | - | -0.458 | 0.247 | -0.425 | 0.253 | -0.431 | 0.247 | -0.384 | 0.273 |
1026840 | HLA-B*07:02 | 9 | 296 | 25 | binary | 0.385 | 0.899 | 0.382 | 0.897 | 0.366 | 0.880 | 0.377 | 0.908 | 0.381 | 0.910 | 0.375 | 0.889 | 0.373 | 0.887 | - | - | - | - | - | - | - | - | 0.364 | 0.888 | 0.387 | 0.903 | 0.388 | 0.902 | 0.402 | 0.917 |
1026840 | HLA-B*58:01 | 9 | 437 | 46 | binary | 0.380 | 0.857 | 0.396 | 0.872 | 0.361 | 0.840 | 0.415 | 0.897 | 0.387 | 0.872 | 0.385 | 0.862 | 0.409 | 0.885 | - | - | - | - | - | - | - | - | 0.391 | 0.868 | 0.400 | 0.879 | 0.408 | 0.884 | 0.477 | 0.949 |
1026840 | HLA-B*58:01 | 9 | 35 | 17 | ic50 | 0.267 | 0.650 | 0.273 | 0.644 | 0.209 | 0.546 | 0.291 | 0.660 | 0.309 | 0.681 | 0.362 | 0.716 | 0.317 | 0.650 | - | - | - | - | - | - | - | - | 0.400 | 0.722 | 0.319 | 0.668 | 0.362 | 0.683 | 0.722 | 0.873 |
1026840 | HLA-B*58:01 | 9 | 35 | 5 | t1/2 | 0.224 | 0.627 | 0.189 | 0.573 | 0.180 | 0.593 | 0.230 | 0.680 | 0.194 | 0.587 | 0.162 | 0.553 | 0.287 | 0.640 | - | - | - | - | - | - | - | - | 0.176 | 0.610 | 0.151 | 0.613 | 0.199 | 0.620 | 0.312 | 0.653 |
1026840 | HLA-C*07:01 | 9 | 439 | 31 | binary | 0.229 | 0.758 | 0.270 | 0.804 | - | - | 0.223 | 0.761 | 0.246 | 0.788 | 0.248 | 0.780 | 0.259 | 0.795 | - | - | - | - | - | - | - | - | 0.194 | 0.725 | 0.134 | 0.654 | 0.129 | 0.648 | - | - |
1026840 | HLA-C*07:01 | 9 | 18 | 12 | ic50 | 0.166 | 0.611 | 0.125 | 0.556 | - | - | 0.026 | 0.396 | 0.009 | 0.583 | -0.181 | 0.542 | 0.154 | 0.667 | - | - | - | - | - | - | - | - | -0.427 | 0.319 | -0.013 | 0.389 | 0.079 | 0.500 | - | - |
1026891 | HLA-A*11:01 | 9 | 22 | 19 | binary | 0.136 | 0.614 | 0.136 | 0.614 | -0.115 | 0.404 | 0.115 | 0.596 | 0.115 | 0.596 | 0.094 | 0.579 | 0.136 | 0.614 | - | - | - | - | - | - | - | - | 0.198 | 0.667 | 0.115 | 0.596 | 0.115 | 0.596 | 0.136 | 0.614 |
1026891 | HLA-A*24:02 | 9 | 21 | 16 | binary | 0.037 | 0.525 | 0.148 | 0.600 | 0.000 | 0.500 | 0.019 | 0.538 | 0.055 | 0.538 | 0.129 | 0.587 | 0.166 | 0.613 | - | - | - | - | - | - | - | - | 0.176 | 0.625 | 0.000 | 0.500 | -0.018 | 0.488 | 0.074 | 0.550 |
1026891 | HLA-B*40:01 | 9 | 20 | 9 | binary | 0.619 | 0.859 | 0.654 | 0.879 | 0.566 | 0.828 | 0.541 | 0.813 | 0.619 | 0.859 | 0.671 | 0.889 | 0.584 | 0.838 | - | - | - | - | - | - | - | - | 0.671 | 0.889 | 0.532 | 0.808 | 0.601 | 0.848 | 0.706 | 0.909 |
1026891 | HLA-B*58:01 | 9 | 20 | 12 | binary | 0.638 | 0.875 | 0.496 | 0.792 | 0.584 | 0.844 | 0.438 | 0.766 | 0.619 | 0.865 | 0.637 | 0.875 | 0.602 | 0.854 | - | - | - | - | - | - | - | - | 0.531 | 0.812 | 0.442 | 0.760 | 0.442 | 0.760 | 0.832 | 0.990 |
1026891 | HLA-C*03:04 | 9 | 20 | 11 | binary | - | - | - | - | - | - | - | - | 0.706 | 0.909 | 0.706 | 0.909 | 0.584 | 0.838 | - | - | - | - | - | - | - | - | 0.532 | 0.808 | - | - | - | - | - | - |
1026891 | HLA-C*07:02 | 9 | 20 | 7 | binary | 0.409 | 0.747 | 0.445 | 0.769 | - | - | 0.409 | 0.747 | 0.318 | 0.692 | 0.245 | 0.648 | 0.445 | 0.769 | - | - | - | - | - | - | - | - | 0.264 | 0.659 | 0.391 | 0.736 | 0.300 | 0.681 | 0.355 | 0.714 |
1026891 | HLA-C*08:01 | 9 | 20 | 12 | binary | - | - | - | - | - | - | - | - | 0.566 | 0.833 | 0.566 | 0.833 | 0.336 | 0.698 | - | - | - | - | - | - | - | - | 0.567 | 0.833 | - | - | - | - | - | - |
1026897 | HLA-B*40:01 | 9 | 18 | 5 | binary | 0.466 | 0.800 | 0.466 | 0.800 | 0.466 | 0.800 | 0.490 | 0.815 | 0.467 | 0.800 | 0.466 | 0.800 | 0.466 | 0.800 | - | - | - | - | - | - | - | - | 0.505 | 0.900 | 0.562 | 0.862 | 0.514 | 0.831 | 0.562 | 0.862 |
1026897 | HLA-B*40:01 | 10 | 12 | 2 | binary | 0.648 | 1.000 | 0.648 | 1.000 | 0.722 | 1.000 | 0.648 | 1.000 | 0.649 | 1.000 | 0.648 | 1.000 | 0.648 | 1.000 | - | - | - | - | - | - | - | - | 0.722 | 1.000 | 0.648 | 1.000 | 0.648 | 1.000 | 0.648 | 1.000 |
1026897 | HLA-B*55:02 | 9 | 11 | 3 | binary | - | - | - | - | - | - | - | - | 0.645 | 0.917 | 0.645 | 0.917 | 0.775 | 1.000 | - | - | - | - | - | - | - | - | 0.616 | 0.896 | - | - | - | - | - | - |
1026897 | HLA-B*58:01 | 9 | 25 | 5 | binary | 0.485 | 0.850 | 0.499 | 0.860 | 0.416 | 0.800 | 0.527 | 0.880 | 0.471 | 0.840 | 0.485 | 0.850 | 0.471 | 0.840 | - | - | - | - | - | - | - | - | 0.472 | 0.840 | 0.541 | 0.890 | 0.527 | 0.880 | 0.485 | 0.850 |
1026897 | HLA-B*58:01 | 10 | 18 | 3 | binary | 0.129 | 0.600 | 0.359 | 0.778 | 0.537 | 0.889 | 0.158 | 0.622 | 0.244 | 0.689 | 0.330 | 0.756 | 0.158 | 0.622 | - | - | - | - | - | - | - | - | 0.217 | 0.667 | 0.101 | 0.578 | 0.129 | 0.600 | 0.388 | 0.800 |
1026941 | HLA-A*02:01 | 9 | 10 | 6 | binary | 0.853 | 1.000 | 0.853 | 1.000 | 0.711 | 0.917 | 0.751 | 0.958 | 0.711 | 0.917 | 0.711 | 0.917 | 0.711 | 0.917 | - | - | - | - | - | - | - | - | 0.853 | 1.000 | 0.782 | 0.958 | 0.711 | 0.917 | 0.853 | 1.000 |
1026941 | HLA-A*02:01 | 9 | 10 | 6 | ic50 | 0.864 | 1.000 | 0.864 | 1.000 | 0.717 | 0.917 | 0.758 | 0.958 | 0.677 | 0.917 | 0.677 | 0.917 | 0.717 | 0.917 | - | - | - | - | - | - | - | - | 0.864 | 1.000 | 0.791 | 0.958 | 0.717 | 0.917 | 0.864 | 1.000 |