MHCI Weekly Benchmark results
Overall scores
Overall scores based on data sets submitted to the IED for the last at least 5 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.
Server | Overall | SRCC | AUC |
---|---|---|---|
ANN 3.4 | 59 | 58 | 59 |
ANN 4.0 | 55 | 57 | 53 |
ARB | 18 | 15 | 21 |
IEDB Consensus | 48 | 48 | 48 |
NetMHCcons | 71 | 71 | 71 |
NetMHCpan 2.8 | 43 | 43 | 44 |
NetMHCpan 3.0 | 56 | 55 | 56 |
NetMHCpan 4.0 BA | - | - | - |
NetMHCpan 4.0 EL | - | - | - |
NetMHCpan 4.1 BA | - | - | - |
NetMHCpan 4.1 EL | - | - | - |
PickPocket | 25 | 24 | 27 |
SMM | 53 | 51 | 55 |
SMMPMBEC | 53 | 51 | 54 |
mhcflurry 1.2.0 | 55 | 58 | 52 |
Data set specific results
Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here
Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.
IEDB Reference |
Allele | Peptide Length |
Peptide Count |
Positive Count |
Measurement type |
ANN 3.4 | ANN 4.0 | ARB | IEDB Consensus | NetMHCcons | NetMHCpan 2.8 | NetMHCpan 3.0 | NetMHCpan 4.0 BA | NetMHCpan 4.0 EL | NetMHCpan 4.1 BA | NetMHCpan 4.1 EL | PickPocket | SMM | SMMPMBEC | mhcflurry 1.2.0 | |||||||||||||||
SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | ||||||
1028228 | HLA-C*03:03 | 9 | 163 | 120 | ic50 | 0.849 | 0.935 | 0.865 | 0.947 | - | - | 0.855 | 0.946 | 0.842 | 0.931 | 0.797 | 0.905 | 0.825 | 0.924 | - | - | - | - | - | - | - | - | 0.806 | 0.905 | 0.854 | 0.946 | 0.842 | 0.936 | 0.778 | 0.873 |
1028229 | HLA-C*04:01 | 9 | 153 | 18 | ic50 | 0.581 | 1.000 | 0.563 | 0.998 | - | - | 0.550 | 0.976 | 0.590 | 0.998 | 0.457 | 0.904 | 0.484 | 0.937 | - | - | - | - | - | - | - | - | 0.394 | 0.853 | 0.556 | 0.972 | 0.586 | 0.996 | 0.404 | 0.851 |
1028230 | HLA-C*05:01 | 9 | 172 | 68 | ic50 | 0.940 | 0.999 | 0.916 | 0.993 | - | - | 0.912 | 0.996 | 0.925 | 0.997 | 0.863 | 0.968 | 0.892 | 0.976 | - | - | - | - | - | - | - | - | 0.836 | 0.946 | 0.911 | 0.996 | 0.899 | 0.990 | 0.803 | 0.906 |
1028231 | HLA-C*06:02 | 9 | 100 | 46 | ic50 | 0.909 | 0.980 | 0.872 | 0.959 | - | - | 0.910 | 0.977 | 0.902 | 0.971 | 0.865 | 0.947 | 0.874 | 0.956 | - | - | - | - | - | - | - | - | 0.819 | 0.932 | 0.915 | 0.982 | 0.902 | 0.976 | 0.771 | 0.899 |
1028232 | HLA-C*07:02 | 9 | 140 | 82 | ic50 | 0.890 | 0.969 | 0.850 | 0.947 | - | - | 0.921 | 0.963 | 0.876 | 0.973 | 0.814 | 0.951 | 0.812 | 0.957 | - | - | - | - | - | - | - | - | 0.762 | 0.909 | 0.921 | 0.961 | 0.914 | 0.965 | 0.673 | 0.860 |
1028233 | HLA-C*08:02 | 9 | 87 | 32 | ic50 | 0.879 | 0.963 | 0.810 | 0.918 | - | - | 0.794 | 0.917 | 0.858 | 0.957 | 0.746 | 0.905 | 0.767 | 0.920 | - | - | - | - | - | - | - | - | 0.646 | 0.831 | 0.791 | 0.915 | 0.786 | 0.924 | 0.597 | 0.794 |
1028234 | HLA-C*14:02 | 9 | 218 | 170 | ic50 | 0.877 | 0.926 | 0.813 | 0.910 | - | - | 0.768 | 0.877 | 0.850 | 0.915 | 0.746 | 0.865 | 0.766 | 0.874 | - | - | - | - | - | - | - | - | 0.670 | 0.829 | 0.766 | 0.875 | 0.784 | 0.879 | 0.742 | 0.883 |
1028235 | HLA-C*15:02 | 9 | 181 | 56 | ic50 | 0.873 | 0.967 | 0.842 | 0.933 | - | - | 0.857 | 0.940 | 0.853 | 0.965 | 0.748 | 0.918 | 0.768 | 0.941 | - | - | - | - | - | - | - | - | 0.737 | 0.870 | 0.846 | 0.940 | 0.861 | 0.941 | 0.699 | 0.896 |
1028282 | HLA-A*01:01 | 9 | 100 | 41 | t1/2 | 0.768 | 0.888 | 0.782 | 0.901 | 0.721 | 0.861 | 0.744 | 0.875 | 0.777 | 0.895 | 0.772 | 0.890 | 0.773 | 0.895 | - | - | - | - | - | - | - | - | 0.609 | 0.861 | 0.766 | 0.880 | 0.762 | 0.888 | 0.795 | 0.862 |
1028285 | HLA-A*02:01 | 9 | 881 | 549 | t1/2 | 0.695 | 0.854 | 0.702 | 0.857 | 0.654 | 0.822 | 0.684 | 0.841 | 0.708 | 0.859 | 0.707 | 0.858 | 0.707 | 0.861 | - | - | - | - | - | - | - | - | 0.681 | 0.839 | 0.697 | 0.851 | 0.694 | 0.849 | 0.711 | 0.865 |
1028285 | HLA-A*02:01 | 10 | 62 | 37 | t1/2 | 0.385 | 0.677 | 0.412 | 0.689 | 0.449 | 0.681 | 0.398 | 0.686 | 0.452 | 0.725 | 0.465 | 0.731 | 0.441 | 0.704 | - | - | - | - | - | - | - | - | 0.434 | 0.684 | 0.405 | 0.688 | 0.393 | 0.682 | 0.422 | 0.695 |
1028285 | HLA-A*02:01 | 11 | 38 | 21 | t1/2 | 0.202 | 0.669 | 0.017 | 0.499 | 0.104 | 0.653 | 0.356 | 0.752 | 0.215 | 0.655 | 0.155 | 0.599 | 0.179 | 0.583 | - | - | - | - | - | - | - | - | 0.319 | 0.686 | 0.357 | 0.751 | 0.197 | 0.689 | 0.339 | 0.703 |
1028286 | HLA-C*12:03 | 9 | 172 | 145 | ic50 | 0.649 | 0.687 | 0.651 | 0.718 | - | - | 0.522 | 0.575 | 0.631 | 0.711 | 0.520 | 0.705 | 0.544 | 0.709 | - | - | - | - | - | - | - | - | 0.434 | 0.648 | 0.522 | 0.574 | 0.607 | 0.610 | 0.634 | 0.807 |
1028287 | HLA-A*11:01 | 9 | 577 | 342 | t1/2 | 0.756 | 0.888 | 0.743 | 0.886 | 0.710 | 0.869 | 0.777 | 0.899 | 0.776 | 0.896 | 0.770 | 0.890 | 0.776 | 0.894 | - | - | - | - | - | - | - | - | 0.597 | 0.807 | 0.784 | 0.901 | 0.783 | 0.901 | 0.803 | 0.911 |
1028287 | HLA-A*11:01 | 11 | 15 | 7 | t1/2 | 0.591 | 0.705 | 0.805 | 0.857 | - | - | 0.725 | 0.786 | 0.630 | 0.750 | 0.664 | 0.768 | 0.787 | 0.839 | - | - | - | - | - | - | - | - | 0.773 | 0.875 | 0.764 | 0.804 | 0.825 | 0.857 | 0.794 | 0.839 |
1028288 | HLA-A*03:01 | 9 | 861 | 332 | t1/2 | 0.616 | 0.803 | 0.604 | 0.795 | 0.603 | 0.803 | 0.630 | 0.817 | 0.645 | 0.817 | 0.645 | 0.817 | 0.624 | 0.807 | - | - | - | - | - | - | - | - | 0.519 | 0.754 | 0.636 | 0.824 | 0.633 | 0.823 | 0.759 | 0.869 |
1028289 | HLA-A*24:02 | 9 | 573 | 249 | t1/2 | 0.700 | 0.850 | 0.699 | 0.856 | 0.637 | 0.826 | 0.695 | 0.859 | 0.724 | 0.864 | 0.697 | 0.852 | 0.703 | 0.859 | - | - | - | - | - | - | - | - | 0.694 | 0.855 | 0.696 | 0.860 | 0.704 | 0.860 | 0.705 | 0.850 |
1028289 | HLA-A*24:02 | 10 | 11 | 6 | t1/2 | 0.664 | 0.767 | 0.645 | 0.733 | -0.036 | 0.367 | 0.389 | 0.633 | 0.764 | 0.833 | 0.845 | 0.900 | 0.755 | 0.833 | - | - | - | - | - | - | - | - | 0.827 | 0.933 | 0.455 | 0.667 | 0.582 | 0.767 | 0.691 | 0.733 |
1028290 | HLA-A*26:01 | 9 | 272 | 85 | t1/2 | 0.692 | 0.855 | 0.670 | 0.843 | 0.605 | 0.848 | 0.649 | 0.841 | 0.697 | 0.859 | 0.684 | 0.853 | 0.690 | 0.856 | - | - | - | - | - | - | - | - | 0.535 | 0.796 | 0.673 | 0.861 | 0.674 | 0.859 | 0.727 | 0.858 |
1028291 | HLA-B*07:02 | 8 | 16 | 6 | t1/2 | 0.638 | 0.792 | 0.542 | 0.783 | -0.198 | 0.467 | 0.556 | 0.750 | 0.642 | 0.817 | 0.607 | 0.850 | 0.629 | 0.833 | - | - | - | - | - | - | - | - | 0.517 | 0.717 | 0.434 | 0.700 | 0.596 | 0.783 | 0.518 | 0.750 |
1028291 | HLA-B*07:02 | 9 | 599 | 377 | t1/2 | 0.711 | 0.886 | 0.716 | 0.882 | 0.546 | 0.784 | 0.675 | 0.864 | 0.722 | 0.889 | 0.710 | 0.880 | 0.716 | 0.883 | - | - | - | - | - | - | - | - | 0.542 | 0.796 | 0.708 | 0.877 | 0.706 | 0.875 | 0.708 | 0.877 |
1028291 | HLA-B*07:02 | 10 | 26 | 16 | t1/2 | 0.415 | 0.653 | 0.455 | 0.625 | 0.364 | 0.637 | 0.615 | 0.697 | 0.365 | 0.625 | 0.297 | 0.606 | 0.394 | 0.612 | - | - | - | - | - | - | - | - | 0.177 | 0.531 | 0.610 | 0.713 | 0.585 | 0.700 | 0.436 | 0.644 |
1028291 | HLA-B*07:02 | 11 | 17 | 10 | t1/2 | 0.339 | 0.700 | 0.484 | 0.800 | - | - | 0.262 | 0.686 | 0.405 | 0.729 | 0.436 | 0.729 | 0.545 | 0.800 | - | - | - | - | - | - | - | - | 0.431 | 0.700 | 0.168 | 0.614 | 0.178 | 0.514 | 0.406 | 0.757 |
1028292 | HLA-B*35:01 | 8 | 10 | 4 | t1/2 | -0.081 | 0.542 | -0.119 | 0.458 | 0.468 | 0.792 | 0.119 | 0.583 | 0.000 | 0.583 | 0.075 | 0.667 | -0.069 | 0.458 | - | - | - | - | - | - | - | - | 0.638 | 0.917 | 0.088 | 0.583 | -0.381 | 0.375 | 0.500 | 0.792 |
1028292 | HLA-B*35:01 | 9 | 550 | 223 | t1/2 | 0.616 | 0.830 | 0.607 | 0.820 | 0.465 | 0.733 | 0.513 | 0.768 | 0.625 | 0.836 | 0.609 | 0.830 | 0.618 | 0.833 | - | - | - | - | - | - | - | - | 0.612 | 0.836 | 0.552 | 0.793 | 0.556 | 0.797 | 0.687 | 0.849 |
1028292 | HLA-B*35:01 | 10 | 15 | 5 | t1/2 | 0.161 | 0.740 | 0.374 | 0.800 | -0.083 | 0.520 | 0.117 | 0.700 | 0.218 | 0.740 | 0.202 | 0.700 | 0.408 | 0.840 | - | - | - | - | - | - | - | - | 0.311 | 0.720 | 0.117 | 0.700 | 0.166 | 0.680 | 0.486 | 0.720 |
1028292 | HLA-B*35:01 | 11 | 17 | 4 | t1/2 | 0.035 | 0.462 | -0.049 | 0.462 | - | - | -0.280 | 0.577 | 0.250 | 0.596 | 0.308 | 0.654 | -0.025 | 0.462 | - | - | - | - | - | - | - | - | 0.598 | 0.615 | -0.280 | 0.577 | -0.626 | 0.404 | 0.287 | 0.558 |
1028293 | HLA-B*15:01 | 9 | 1070 | 855 | t1/2 | 0.429 | 0.734 | 0.447 | 0.748 | 0.286 | 0.625 | 0.379 | 0.691 | 0.463 | 0.759 | 0.460 | 0.762 | 0.469 | 0.781 | - | - | - | - | - | - | - | - | 0.261 | 0.622 | 0.441 | 0.729 | 0.444 | 0.726 | 0.546 | 0.818 |
1028294 | HLA-B*40:01 | 9 | 302 | 30 | t1/2 | 0.588 | 0.659 | 0.587 | 0.650 | 0.454 | 0.666 | 0.550 | 0.674 | 0.564 | 0.642 | 0.528 | 0.615 | 0.522 | 0.623 | - | - | - | - | - | - | - | - | 0.452 | 0.614 | 0.549 | 0.673 | 0.532 | 0.656 | 0.595 | 0.651 |