MHCI Weekly Benchmark results
Overall scores
Overall scores based on data sets submitted to the IED for the last at least 13 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.
Server | Overall | SRCC | AUC |
---|---|---|---|
ANN 3.4 | 53 | 52 | 54 |
ANN 4.0 | 51 | 51 | 52 |
ARB | 29 | 27 | 31 |
IEDB Consensus | 55 | 56 | 55 |
NetMHCcons | 57 | 55 | 60 |
NetMHCpan 2.8 | 60 | 61 | 59 |
NetMHCpan 3.0 | 62 | 58 | 65 |
NetMHCpan 4.0 BA | 68 | 64 | 71 |
NetMHCpan 4.0 EL | 46 | 42 | 51 |
NetMHCpan 4.1 BA | 68 | 64 | 71 |
NetMHCpan 4.1 EL | 44 | 39 | 49 |
PickPocket | 49 | 49 | 49 |
SMM | 52 | 54 | 49 |
SMMPMBEC | 54 | 56 | 52 |
mhcflurry 1.2.0 | 64 | 62 | 66 |
Data set specific results
Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here
Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.
IEDB Reference |
Allele | Peptide Length |
Peptide Count |
Positive Count |
Measurement type |
ANN 3.4 | ANN 4.0 | ARB | IEDB Consensus | NetMHCcons | NetMHCpan 2.8 | NetMHCpan 3.0 | NetMHCpan 4.0 BA | NetMHCpan 4.0 EL | NetMHCpan 4.1 BA | NetMHCpan 4.1 EL | PickPocket | SMM | SMMPMBEC | mhcflurry 1.2.0 | |||||||||||||||
SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | ||||||
1037971 | HLA-B*15:01 | 9 | 12 | 4 | ic50 | 0.552 | 0.812 | 0.636 | 0.875 | 0.378 | 0.719 | 0.476 | 0.781 | 0.657 | 0.875 | 0.720 | 0.938 | 0.692 | 0.906 | 0.685 | 0.906 | 0.734 | 0.969 | 0.685 | 0.875 | 0.643 | 0.906 | 0.671 | 0.875 | 0.490 | 0.750 | 0.490 | 0.750 | 0.643 | 0.875 |
1037895 | HLA-A*02:01 | 9 | 12 | 8 | ic50 | 0.692 | 0.750 | 0.643 | 0.656 | 0.643 | 0.719 | 0.677 | 0.703 | 0.664 | 0.719 | 0.692 | 0.719 | 0.497 | 0.656 | 0.587 | 0.719 | 0.182 | 0.500 | 0.692 | 0.719 | 0.126 | 0.469 | 0.503 | 0.562 | 0.657 | 0.688 | 0.699 | 0.688 | 0.790 | 0.781 |
1037895 | HLA-A*02:01 | 10 | 11 | 6 | ic50 | 0.555 | 0.700 | 0.573 | 0.700 | 0.536 | 0.767 | 0.424 | 0.600 | 0.636 | 0.733 | 0.691 | 0.733 | 0.700 | 0.833 | 0.573 | 0.767 | 0.445 | 0.700 | 0.664 | 0.800 | 0.409 | 0.700 | 0.296 | 0.550 | 0.355 | 0.567 | 0.355 | 0.567 | 0.491 | 0.600 |
1038020 | HLA-A*02:01 | 9 | 14 | 6 | t1/2 | -0.200 | 0.396 | -0.215 | 0.396 | -0.163 | 0.458 | -0.303 | 0.354 | -0.203 | 0.375 | -0.123 | 0.417 | -0.010 | 0.479 | -0.010 | 0.479 | -0.128 | 0.375 | -0.075 | 0.438 | -0.195 | 0.312 | -0.183 | 0.417 | -0.295 | 0.354 | -0.230 | 0.396 | -0.198 | 0.417 |
1038478 | HLA-A*02:01 | 9 | 25 | 12 | binary | 0.856 | 0.994 | 0.855 | 0.994 | 0.811 | 0.968 | 0.825 | 0.974 | 0.855 | 0.994 | 0.844 | 0.987 | 0.855 | 0.994 | 0.855 | 0.994 | 0.855 | 0.994 | 0.855 | 0.994 | 0.727 | 0.920 | 0.827 | 0.978 | 0.822 | 0.974 | 0.822 | 0.974 | 0.833 | 0.981 |
1038307 | HLA-A*02:01 | 9 | 10 | 6 | binary | 0.711 | 0.917 | 0.711 | 0.917 | 0.569 | 0.833 | 0.711 | 0.917 | 0.711 | 0.917 | 0.782 | 0.958 | 0.711 | 0.917 | 0.782 | 0.958 | 0.782 | 0.958 | 0.782 | 0.958 | 0.853 | 1.000 | 0.711 | 0.917 | 0.711 | 0.917 | 0.711 | 0.917 | 0.782 | 0.958 |
1038759 | H-2-Kb | 9 | 12 | 9 | binary | -0.084 | 0.444 | -0.028 | 0.481 | 0.084 | 0.556 | 0.363 | 0.741 | 0.028 | 0.519 | -0.084 | 0.444 | -0.084 | 0.444 | -0.139 | 0.407 | -0.362 | 0.259 | -0.084 | 0.444 | -0.307 | 0.296 | 0.195 | 0.630 | 0.362 | 0.741 | 0.084 | 0.556 | -0.307 | 0.296 |
1038493 | SLA-1*13:01 | 9 | 46 | 39 | binary | - | - | - | - | - | - | - | - | -0.451 | 0.141 | -0.490 | 0.106 | -0.417 | 0.165 | -0.440 | 0.147 | -0.458 | 0.132 | -0.476 | 0.117 | -0.390 | 0.187 | -0.171 | 0.363 | - | - | - | - | - | - |
1037887 | H-2-Kd | 8 | 22 | 2 | ic50 | 0.481 | 0.550 | 0.412 | 0.625 | - | - | 0.542 | 0.575 | 0.471 | 0.550 | 0.469 | 0.575 | 0.569 | 0.650 | 0.535 | 0.650 | 0.281 | 0.925 | 0.527 | 0.650 | 0.297 | 0.925 | 0.413 | 0.600 | 0.617 | 0.575 | 0.565 | 0.575 | 0.596 | 0.675 |
1037887 | H-2-Kd | 9 | 38 | 16 | ic50 | 0.778 | 0.946 | 0.792 | 0.972 | 0.727 | 0.960 | 0.797 | 0.967 | 0.797 | 0.960 | 0.827 | 0.977 | 0.793 | 0.952 | 0.820 | 0.966 | 0.460 | 0.790 | 0.835 | 0.974 | 0.332 | 0.707 | 0.817 | 0.980 | 0.791 | 0.969 | 0.798 | 0.969 | 0.853 | 0.974 |
1037887 | H-2-Kd | 10 | 34 | 11 | ic50 | 0.454 | 0.609 | 0.299 | 0.502 | 0.155 | 0.549 | 0.412 | 0.573 | 0.362 | 0.561 | 0.150 | 0.439 | 0.288 | 0.518 | 0.326 | 0.538 | 0.312 | 0.609 | 0.318 | 0.542 | 0.189 | 0.549 | 0.209 | 0.470 | 0.579 | 0.708 | 0.575 | 0.700 | 0.579 | 0.664 |
1037887 | H-2-Kd | 11 | 38 | 11 | ic50 | 0.706 | 0.835 | 0.661 | 0.791 | - | - | 0.770 | 0.828 | 0.648 | 0.815 | 0.557 | 0.778 | 0.614 | 0.815 | 0.627 | 0.811 | 0.421 | 0.721 | 0.649 | 0.832 | 0.537 | 0.764 | 0.539 | 0.774 | 0.790 | 0.832 | 0.788 | 0.842 | 0.801 | 0.865 |
1039330 | HLA-A*02:01 | 9 | 28 | 2 | binary | 0.378 | 0.923 | 0.378 | 0.923 | 0.309 | 0.846 | 0.275 | 0.808 | 0.378 | 0.923 | 0.343 | 0.885 | 0.343 | 0.885 | 0.378 | 0.923 | 0.137 | 0.654 | 0.395 | 0.942 | 0.120 | 0.635 | 0.206 | 0.731 | 0.258 | 0.788 | 0.275 | 0.808 | 0.378 | 0.923 |
1039262 | HLA-A*02:01 | 9 | 11 | 8 | binary | 0.194 | 0.625 | 0.129 | 0.583 | 0.065 | 0.542 | 0.065 | 0.542 | 0.065 | 0.542 | 0.065 | 0.542 | 0.065 | 0.542 | 0.129 | 0.583 | -0.065 | 0.458 | 0.000 | 0.500 | 0.162 | 0.604 | 0.065 | 0.542 | 0.065 | 0.542 | 0.065 | 0.542 | 0.129 | 0.583 |
1039262 | HLA-B*08:01 | 9 | 11 | 2 | binary | 0.671 | 1.000 | 0.596 | 0.944 | 0.522 | 0.889 | 0.522 | 0.889 | 0.671 | 1.000 | 0.671 | 1.000 | 0.671 | 1.000 | 0.671 | 1.000 | 0.522 | 0.889 | 0.671 | 1.000 | 0.671 | 1.000 | 0.447 | 0.833 | 0.596 | 0.944 | 0.671 | 1.000 | 0.671 | 1.000 |
1039262 | HLA-B*15:01 | 9 | 11 | 7 | binary | 0.418 | 0.750 | 0.418 | 0.750 | 0.478 | 0.786 | 0.538 | 0.821 | 0.299 | 0.679 | 0.299 | 0.679 | 0.418 | 0.750 | 0.478 | 0.786 | 0.299 | 0.679 | 0.478 | 0.786 | 0.299 | 0.679 | 0.539 | 0.821 | 0.478 | 0.786 | 0.598 | 0.857 | 0.478 | 0.786 |
1039262 | HLA-B*35:01 | 9 | 14 | 11 | binary | 0.151 | 0.606 | 0.194 | 0.636 | 0.497 | 0.848 | 0.238 | 0.667 | 0.151 | 0.606 | 0.022 | 0.515 | 0.410 | 0.788 | 0.453 | 0.818 | 0.540 | 0.879 | 0.281 | 0.697 | 0.540 | 0.879 | 0.584 | 0.909 | 0.238 | 0.667 | 0.238 | 0.667 | 0.238 | 0.667 |
1039262 | HLA-B*39:01 | 9 | 10 | 4 | binary | 0.213 | 0.625 | 0.284 | 0.667 | 0.071 | 0.542 | 0.497 | 0.792 | 0.569 | 0.833 | 0.853 | 1.000 | 0.853 | 1.000 | 0.853 | 1.000 | 0.711 | 0.917 | 0.853 | 1.000 | 0.640 | 0.875 | 0.711 | 0.917 | 0.569 | 0.833 | 0.569 | 0.833 | 0.569 | 0.833 |
1039262 | HLA-B*52:01 | 9 | 12 | 3 | binary | - | - | - | - | - | - | - | - | -0.139 | 0.407 | -0.139 | 0.407 | 0.307 | 0.704 | 0.362 | 0.741 | 0.028 | 0.519 | 0.251 | 0.667 | 0.418 | 0.778 | 0.307 | 0.704 | - | - | - | - | - | - |
1039262 | HLA-C*07:01 | 9 | 16 | 5 | binary | 0.219 | 0.636 | 0.453 | 0.782 | - | - | 0.483 | 0.800 | 0.424 | 0.764 | 0.483 | 0.800 | 0.395 | 0.745 | 0.219 | 0.636 | -0.102 | 0.436 | 0.336 | 0.709 | -0.015 | 0.491 | 0.687 | 0.927 | 0.483 | 0.800 | 0.190 | 0.618 | - | - |
1038983 | HLA-A*02:01 | 9 | 19 | 2 | ic50 | 0.464 | 0.838 | 0.467 | 0.824 | 0.528 | 0.794 | 0.386 | 0.853 | 0.433 | 0.794 | 0.419 | 0.794 | 0.516 | 0.882 | 0.463 | 0.912 | 0.518 | 0.971 | 0.458 | 0.941 | 0.426 | 0.882 | 0.505 | 0.794 | 0.495 | 0.853 | 0.495 | 0.824 | 0.398 | 0.853 |
1038983 | HLA-A*03:01 | 9 | 14 | 4 | ic50 | 0.741 | 0.900 | 0.767 | 0.950 | 0.521 | 0.800 | 0.745 | 0.900 | 0.723 | 0.900 | 0.723 | 0.850 | 0.670 | 0.850 | 0.640 | 0.825 | 0.833 | 0.900 | 0.640 | 0.825 | 0.780 | 0.875 | 0.323 | 0.650 | 0.692 | 0.825 | 0.670 | 0.825 | 0.644 | 0.875 |
1038983 | HLA-A*03:01 | 10 | 13 | 3 | ic50 | 0.746 | 1.000 | 0.751 | 0.933 | 0.531 | 0.900 | 0.779 | 0.933 | 0.729 | 1.000 | 0.735 | 1.000 | 0.707 | 0.933 | 0.707 | 0.933 | 0.677 | 0.900 | 0.696 | 0.900 | 0.669 | 0.867 | 0.730 | 1.000 | 0.779 | 0.900 | 0.748 | 0.900 | 0.726 | 1.000 |
1038983 | HLA-A*24:02 | 9 | 16 | 3 | ic50 | 0.274 | 0.692 | 0.400 | 0.769 | 0.371 | 0.769 | 0.435 | 0.744 | 0.318 | 0.692 | 0.406 | 0.667 | 0.347 | 0.692 | 0.326 | 0.667 | 0.509 | 0.795 | 0.388 | 0.692 | 0.485 | 0.821 | 0.462 | 0.744 | 0.421 | 0.718 | 0.388 | 0.718 | 0.335 | 0.692 |
1038983 | HLA-B*07:02 | 9 | 15 | 4 | ic50 | 0.399 | 0.534 | 0.361 | 0.523 | -0.275 | 0.250 | 0.413 | 0.534 | 0.311 | 0.477 | 0.350 | 0.545 | 0.368 | 0.659 | 0.311 | 0.636 | 0.393 | 0.545 | 0.375 | 0.636 | 0.325 | 0.591 | 0.280 | 0.545 | 0.500 | 0.523 | 0.414 | 0.523 | 0.214 | 0.500 |
1039280 | HLA-A*02:01 | 9 | 41 | 23 | binary | 0.509 | 0.796 | 0.498 | 0.790 | 0.386 | 0.725 | 0.622 | 0.861 | 0.503 | 0.792 | 0.507 | 0.795 | 0.615 | 0.857 | 0.582 | 0.838 | 0.390 | 0.727 | 0.557 | 0.824 | 0.474 | 0.775 | 0.573 | 0.833 | 0.619 | 0.860 | 0.623 | 0.862 | 0.528 | 0.807 |
1039423 | HLA-A*02:01 | 9 | 25 | 4 | ic50 | 0.502 | 0.750 | 0.560 | 0.726 | 0.375 | 0.714 | 0.392 | 0.738 | 0.539 | 0.786 | 0.574 | 0.786 | 0.523 | 0.762 | 0.560 | 0.798 | 0.557 | 0.869 | 0.608 | 0.857 | 0.516 | 0.857 | 0.560 | 0.798 | 0.452 | 0.762 | 0.464 | 0.774 | 0.551 | 0.774 |
1039423 | HLA-A*03:01 | 9 | 12 | 3 | ic50 | 0.701 | 0.889 | 0.606 | 0.889 | 0.718 | 0.852 | 0.834 | 0.963 | 0.809 | 0.963 | 0.760 | 0.963 | 0.697 | 0.889 | 0.732 | 0.926 | 0.613 | 0.852 | 0.655 | 0.889 | - | - | 0.582 | 0.759 | 0.732 | 0.889 | 0.743 | 0.889 | 0.736 | 0.889 |
1039423 | HLA-A*24:02 | 9 | 19 | 10 | ic50 | 0.416 | 0.544 | 0.472 | 0.622 | 0.337 | 0.567 | 0.346 | 0.522 | 0.553 | 0.689 | 0.612 | 0.811 | 0.700 | 0.856 | 0.675 | 0.844 | 0.749 | 0.911 | 0.621 | 0.833 | 0.649 | 0.878 | 0.483 | 0.672 | 0.138 | 0.394 | 0.196 | 0.444 | 0.416 | 0.578 |
1039423 | HLA-A*24:02 | 10 | 15 | 8 | ic50 | 0.561 | 0.857 | 0.589 | 0.875 | 0.436 | 0.750 | 0.564 | 0.857 | 0.550 | 0.875 | 0.582 | 0.893 | 0.536 | 0.875 | 0.554 | 0.875 | 0.471 | 0.839 | 0.496 | 0.857 | 0.425 | 0.804 | 0.504 | 0.857 | 0.454 | 0.768 | 0.450 | 0.821 | 0.621 | 0.875 |
1039423 | HLA-B*07:02 | 9 | 15 | 5 | ic50 | 0.742 | 0.940 | 0.717 | 0.940 | 0.434 | 0.780 | 0.705 | 0.940 | 0.811 | 0.960 | 0.811 | 0.960 | 0.735 | 1.000 | 0.795 | 1.000 | 0.652 | 0.860 | 0.775 | 0.980 | 0.746 | 0.920 | 0.440 | 0.780 | 0.712 | 0.920 | 0.737 | 0.940 | 0.708 | 0.960 |