MHCI Weekly Benchmark results
Overall scores
Overall scores based on data sets submitted to the IED for the last at least 10 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.
Server | Overall | SRCC | AUC |
---|---|---|---|
ANN 3.4 | 48 | 45 | 50 |
ANN 4.0 | 63 | 62 | 65 |
ARB | 32 | 31 | 34 |
IEDB Consensus | 60 | 59 | 61 |
NetMHCcons | 63 | 60 | 66 |
NetMHCpan 2.8 | 66 | 65 | 67 |
NetMHCpan 3.0 | 72 | 70 | 74 |
NetMHCpan 4.0 BA | 75 | 75 | 76 |
NetMHCpan 4.0 EL | 42 | 40 | 44 |
NetMHCpan 4.1 BA | 74 | 72 | 76 |
NetMHCpan 4.1 EL | 46 | 44 | 47 |
PickPocket | 49 | 47 | 51 |
SMM | 49 | 48 | 49 |
SMMPMBEC | 50 | 48 | 52 |
mhcflurry 1.2.0 | 55 | 55 | 56 |
Data set specific results
Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here
Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.
IEDB Reference |
Allele | Peptide Length |
Peptide Count |
Positive Count |
Measurement type |
ANN 3.4 | ANN 4.0 | ARB | IEDB Consensus | NetMHCcons | NetMHCpan 2.8 | NetMHCpan 3.0 | NetMHCpan 4.0 BA | NetMHCpan 4.0 EL | NetMHCpan 4.1 BA | NetMHCpan 4.1 EL | PickPocket | SMM | SMMPMBEC | mhcflurry 1.2.0 | |||||||||||||||
SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | ||||||
1039423 | HLA-A*02:01 | 9 | 25 | 4 | ic50 | 0.502 | 0.750 | 0.560 | 0.726 | 0.375 | 0.714 | 0.392 | 0.738 | 0.539 | 0.786 | 0.574 | 0.786 | 0.523 | 0.762 | 0.560 | 0.798 | 0.557 | 0.869 | 0.608 | 0.857 | 0.516 | 0.857 | 0.560 | 0.798 | 0.452 | 0.762 | 0.464 | 0.774 | 0.551 | 0.774 |
1039423 | HLA-A*03:01 | 9 | 12 | 3 | ic50 | 0.701 | 0.889 | 0.606 | 0.889 | 0.718 | 0.852 | 0.834 | 0.963 | 0.809 | 0.963 | 0.760 | 0.963 | 0.697 | 0.889 | 0.732 | 0.926 | 0.613 | 0.852 | 0.655 | 0.889 | - | - | 0.582 | 0.759 | 0.732 | 0.889 | 0.743 | 0.889 | 0.736 | 0.889 |
1039423 | HLA-A*24:02 | 9 | 19 | 10 | ic50 | 0.416 | 0.544 | 0.472 | 0.622 | 0.337 | 0.567 | 0.346 | 0.522 | 0.553 | 0.689 | 0.612 | 0.811 | 0.700 | 0.856 | 0.675 | 0.844 | 0.749 | 0.911 | 0.621 | 0.833 | 0.649 | 0.878 | 0.483 | 0.672 | 0.138 | 0.394 | 0.196 | 0.444 | 0.416 | 0.578 |
1039423 | HLA-A*24:02 | 10 | 15 | 8 | ic50 | 0.561 | 0.857 | 0.589 | 0.875 | 0.436 | 0.750 | 0.564 | 0.857 | 0.550 | 0.875 | 0.582 | 0.893 | 0.536 | 0.875 | 0.554 | 0.875 | 0.471 | 0.839 | 0.496 | 0.857 | 0.425 | 0.804 | 0.504 | 0.857 | 0.454 | 0.768 | 0.450 | 0.821 | 0.621 | 0.875 |
1039423 | HLA-B*07:02 | 9 | 15 | 5 | ic50 | 0.742 | 0.940 | 0.717 | 0.940 | 0.434 | 0.780 | 0.705 | 0.940 | 0.811 | 0.960 | 0.811 | 0.960 | 0.735 | 1.000 | 0.795 | 1.000 | 0.652 | 0.860 | 0.775 | 0.980 | 0.746 | 0.920 | 0.440 | 0.780 | 0.712 | 0.920 | 0.737 | 0.940 | 0.708 | 0.960 |
1039777 | H-2-Db | 9 | 10 | 3 | ic50 | 0.705 | 1.000 | 0.925 | 1.000 | 0.772 | 0.952 | 0.860 | 1.000 | 0.705 | 1.000 | 0.743 | 1.000 | 0.821 | 1.000 | 0.834 | 1.000 | 0.666 | 1.000 | 0.821 | 1.000 | 0.743 | 1.000 | 0.705 | 0.905 | 0.860 | 1.000 | 0.860 | 1.000 | 0.925 | 1.000 |
1039777 | H-2-Kb | 8 | 14 | 4 | ic50 | 0.636 | 0.850 | 0.666 | 0.925 | 0.636 | 0.900 | 0.645 | 0.850 | 0.707 | 0.900 | 0.705 | 0.875 | 0.801 | 0.950 | 0.824 | 0.975 | 0.787 | 0.975 | 0.805 | 0.925 | 0.821 | 1.000 | 0.549 | 0.725 | 0.581 | 0.825 | 0.581 | 0.825 | 0.778 | 0.950 |
1039777 | H-2-Kb | 9 | 10 | 2 | ic50 | 0.648 | 0.938 | 0.770 | 1.000 | 0.442 | 0.750 | 0.733 | 0.938 | 0.818 | 1.000 | 0.855 | 1.000 | 0.830 | 1.000 | 0.842 | 1.000 | 0.830 | 0.875 | 0.818 | 1.000 | 0.855 | 0.938 | 0.782 | 1.000 | 0.661 | 0.875 | 0.661 | 0.875 | 0.794 | 0.938 |
1039793 | HLA-A*02:01 | 9 | 26 | 21 | binary | 0.639 | 0.971 | 0.644 | 0.971 | 0.670 | 0.990 | 0.679 | 0.995 | 0.657 | 0.981 | 0.618 | 0.952 | 0.631 | 0.962 | 0.657 | 0.981 | 0.228 | 0.667 | 0.644 | 0.971 | 0.319 | 0.733 | 0.670 | 0.990 | 0.670 | 0.990 | 0.670 | 0.990 | 0.670 | 0.990 |
1039793 | HLA-A*02:03 | 9 | 20 | 15 | binary | 0.542 | 0.860 | 0.531 | 0.853 | 0.110 | 0.573 | 0.421 | 0.780 | 0.551 | 0.867 | 0.531 | 0.853 | 0.551 | 0.867 | 0.601 | 0.900 | 0.431 | 0.787 | 0.571 | 0.880 | 0.451 | 0.800 | 0.471 | 0.813 | 0.431 | 0.787 | 0.431 | 0.787 | 0.411 | 0.773 |
1039793 | HLA-A*02:06 | 9 | 17 | 10 | binary | 0.122 | 0.571 | - | - | 0.146 | 0.586 | 0.195 | 0.614 | 0.268 | 0.657 | 0.268 | 0.657 | 0.317 | 0.686 | 0.317 | 0.686 | 0.073 | 0.543 | 0.342 | 0.700 | 0.098 | 0.557 | 0.146 | 0.586 | 0.171 | 0.600 | 0.220 | 0.629 | 0.342 | 0.700 |
1039793 | HLA-A*11:01 | 9 | 29 | 22 | binary | 0.414 | 0.779 | 0.443 | 0.799 | 0.347 | 0.734 | 0.448 | 0.802 | 0.453 | 0.805 | 0.472 | 0.818 | 0.482 | 0.825 | 0.482 | 0.825 | 0.472 | 0.818 | 0.482 | 0.825 | 0.496 | 0.834 | 0.453 | 0.805 | 0.433 | 0.792 | 0.433 | 0.792 | 0.501 | 0.838 |
1039793 | HLA-A*24:02 | 10 | 13 | 7 | binary | 0.660 | 0.881 | 0.660 | 0.881 | 0.495 | 0.786 | 0.743 | 0.929 | 0.701 | 0.905 | 0.619 | 0.857 | 0.784 | 0.952 | 0.742 | 0.929 | 0.742 | 0.929 | 0.742 | 0.929 | 0.784 | 0.952 | 0.640 | 0.869 | 0.660 | 0.881 | 0.577 | 0.833 | 0.536 | 0.810 |
1039793 | HLA-A*33:03 | 9 | 21 | 16 | binary | - | - | - | - | - | - | - | - | 0.037 | 0.525 | 0.037 | 0.525 | 0.037 | 0.525 | 0.129 | 0.587 | 0.065 | 0.544 | 0.055 | 0.538 | -0.037 | 0.475 | 0.102 | 0.569 | - | - | - | - | - | - |
1039752 | HLA-A*03:01 | 9 | 24 | 16 | ic50 | 0.236 | 0.641 | 0.196 | 0.586 | 0.351 | 0.672 | 0.187 | 0.488 | 0.251 | 0.648 | 0.217 | 0.625 | 0.272 | 0.594 | 0.262 | 0.625 | 0.471 | 0.727 | 0.278 | 0.648 | - | - | -0.056 | 0.500 | 0.083 | 0.395 | 0.085 | 0.406 | 0.222 | 0.539 |
1039752 | HLA-B*27:05 | 9 | 25 | 21 | ic50 | 0.411 | 0.851 | 0.316 | 0.690 | 0.054 | 0.750 | 0.481 | 0.690 | 0.445 | 0.869 | 0.438 | 0.810 | 0.359 | 0.726 | 0.486 | 0.702 | 0.146 | 0.524 | 0.279 | 0.643 | 0.147 | 0.565 | 0.071 | 0.548 | 0.458 | 0.869 | 0.394 | 0.917 | 0.217 | 0.714 |
1040276 | HLA-A*02:01 | 9 | 21 | 14 | binary | 0.551 | 0.837 | 0.500 | 0.806 | 0.367 | 0.724 | 0.393 | 0.755 | 0.551 | 0.837 | 0.534 | 0.827 | 0.500 | 0.806 | 0.500 | 0.806 | 0.350 | 0.714 | 0.551 | 0.837 | 0.350 | 0.714 | 0.450 | 0.776 | 0.392 | 0.750 | 0.467 | 0.786 | 0.150 | 0.592 |
1040276 | HLA-A*02:01 | 10 | 11 | 7 | binary | -0.060 | 0.464 | 0.179 | 0.607 | 0.060 | 0.536 | 0.120 | 0.571 | -0.120 | 0.429 | -0.120 | 0.429 | 0.418 | 0.750 | 0.179 | 0.607 | 0.060 | 0.536 | 0.179 | 0.607 | 0.120 | 0.571 | -0.299 | 0.321 | 0.000 | 0.500 | 0.000 | 0.500 | -0.179 | 0.393 |
1038337 | HLA-A*26:01 | 9 | 13 | 2 | binary | -0.057 | 0.455 | 0.057 | 0.545 | -0.171 | 0.364 | -0.171 | 0.364 | -0.114 | 0.409 | -0.114 | 0.409 | -0.228 | 0.318 | 0.000 | 0.500 | -0.114 | 0.409 | -0.057 | 0.455 | -0.285 | 0.273 | -0.456 | 0.136 | -0.342 | 0.227 | -0.228 | 0.318 | 0.057 | 0.545 |
1038337 | HLA-A*26:01 | 10 | 11 | 2 | binary | 0.075 | 0.556 | 0.149 | 0.611 | -0.037 | 0.667 | 0.187 | 0.806 | 0.000 | 0.500 | 0.000 | 0.500 | 0.149 | 0.611 | 0.224 | 0.667 | -0.149 | 0.389 | 0.224 | 0.667 | -0.037 | 0.500 | 0.157 | 0.750 | 0.298 | 0.722 | 0.149 | 0.611 | 0.298 | 0.722 |
1016643 | HLA-A*02:01 | 9 | 14 | 9 | binary | 0.759 | 0.956 | 0.832 | 1.000 | 0.721 | 0.933 | 0.834 | 1.000 | 0.795 | 0.978 | 0.795 | 0.978 | 0.832 | 1.000 | 0.832 | 1.000 | 0.721 | 0.933 | 0.832 | 1.000 | 0.721 | 0.933 | 0.795 | 0.978 | 0.832 | 1.000 | 0.832 | 1.000 | 0.795 | 0.978 |
1040736 | HLA-C*08:02 | 9 | 17 | 14 | binary | 0.567 | 0.929 | 0.598 | 0.952 | - | - | 0.584 | 0.940 | 0.630 | 0.976 | 0.630 | 0.976 | 0.630 | 0.976 | 0.598 | 0.952 | 0.598 | 0.952 | 0.598 | 0.952 | 0.567 | 0.929 | 0.661 | 1.000 | 0.505 | 0.881 | 0.661 | 1.000 | 0.504 | 0.881 |
1041184 | HLA-A*24:02 | 9 | 12 | 10 | binary | 0.324 | 0.750 | 0.389 | 0.800 | 0.324 | 0.750 | 0.423 | 0.850 | 0.194 | 0.650 | 0.194 | 0.650 | 0.259 | 0.700 | 0.324 | 0.750 | -0.259 | 0.300 | 0.389 | 0.800 | -0.259 | 0.300 | 0.324 | 0.750 | 0.389 | 0.800 | 0.453 | 0.850 | 0.518 | 0.900 |
1040281 | HLA-A*01:01 | 9 | 16 | 2 | binary | 0.574 | 1.000 | 0.574 | 1.000 | 0.574 | 1.000 | 0.575 | 1.000 | 0.574 | 1.000 | 0.574 | 1.000 | 0.574 | 1.000 | 0.574 | 1.000 | - | - | 0.574 | 1.000 | 0.574 | 1.000 | 0.578 | 1.000 | 0.574 | 1.000 | 0.574 | 1.000 | 0.574 | 1.000 |
1040281 | HLA-A*02:01 | 9 | 16 | 10 | binary | 0.448 | 0.767 | 0.504 | 0.800 | 0.476 | 0.783 | 0.406 | 0.750 | 0.392 | 0.733 | 0.448 | 0.767 | 0.392 | 0.733 | 0.392 | 0.733 | - | - | 0.392 | 0.733 | 0.448 | 0.767 | 0.519 | 0.808 | 0.448 | 0.767 | 0.448 | 0.767 | 0.392 | 0.733 |
1040281 | HLA-A*02:03 | 9 | 16 | 7 | binary | 0.342 | 0.698 | 0.424 | 0.746 | 0.424 | 0.746 | 0.396 | 0.730 | 0.424 | 0.746 | 0.533 | 0.810 | 0.506 | 0.794 | 0.506 | 0.794 | 0.533 | 0.810 | 0.506 | 0.794 | 0.506 | 0.794 | 0.506 | 0.794 | 0.342 | 0.698 | 0.342 | 0.698 | 0.451 | 0.762 |
1040281 | HLA-A*03:01 | 9 | 16 | 4 | binary | 0.595 | 0.896 | 0.626 | 0.917 | 0.532 | 0.854 | 0.626 | 0.917 | 0.564 | 0.875 | 0.564 | 0.875 | 0.470 | 0.812 | 0.470 | 0.812 | 0.438 | 0.792 | 0.532 | 0.854 | 0.470 | 0.812 | 0.220 | 0.646 | 0.501 | 0.833 | 0.532 | 0.854 | 0.470 | 0.812 |
1040281 | HLA-A*11:01 | 9 | 16 | 3 | binary | 0.261 | 0.692 | 0.261 | 0.692 | 0.330 | 0.744 | 0.226 | 0.718 | 0.191 | 0.641 | 0.191 | 0.641 | 0.295 | 0.718 | 0.122 | 0.590 | -0.191 | 0.359 | 0.052 | 0.538 | 0.087 | 0.564 | 0.435 | 0.821 | 0.261 | 0.692 | 0.191 | 0.641 | 0.365 | 0.769 |
1040281 | HLA-A*23:01 | 9 | 16 | 6 | binary | 0.756 | 0.950 | 0.812 | 0.983 | 0.756 | 0.950 | 0.812 | 0.983 | 0.812 | 0.983 | 0.840 | 1.000 | 0.840 | 1.000 | 0.812 | 0.983 | 0.588 | 0.850 | 0.812 | 0.983 | 0.420 | 0.750 | 0.785 | 0.967 | 0.812 | 0.983 | 0.784 | 0.967 | 0.784 | 0.967 |
1040281 | HLA-A*24:02 | 9 | 16 | 3 | binary | 0.156 | 0.615 | 0.122 | 0.590 | -0.017 | 0.487 | 0.156 | 0.615 | 0.122 | 0.590 | 0.156 | 0.615 | 0.191 | 0.641 | 0.191 | 0.641 | 0.191 | 0.641 | 0.226 | 0.667 | 0.052 | 0.538 | 0.017 | 0.513 | 0.087 | 0.564 | 0.122 | 0.590 | 0.156 | 0.615 |
1040281 | HLA-A*31:01 | 9 | 16 | 2 | binary | 0.123 | 0.607 | 0.082 | 0.571 | 0.041 | 0.536 | 0.164 | 0.643 | - | - | -0.123 | 0.393 | 0.000 | 0.500 | 0.000 | 0.500 | -0.082 | 0.429 | -0.041 | 0.464 | -0.164 | 0.357 | 0.000 | 0.500 | 0.164 | 0.643 | - | - | 0.041 | 0.536 |
1040281 | HLA-B*15:01 | 9 | 16 | 7 | binary | 0.260 | 0.651 | 0.396 | 0.730 | 0.041 | 0.524 | 0.343 | 0.698 | 0.328 | 0.690 | 0.451 | 0.762 | 0.478 | 0.778 | 0.424 | 0.746 | 0.506 | 0.794 | 0.424 | 0.746 | 0.506 | 0.794 | 0.438 | 0.762 | 0.287 | 0.667 | 0.287 | 0.667 | 0.287 | 0.667 |
1040281 | HLA-B*40:01 | 9 | 16 | 2 | binary | 0.574 | 1.000 | 0.574 | 1.000 | 0.369 | 0.821 | 0.576 | 1.000 | 0.574 | 1.000 | 0.574 | 1.000 | 0.574 | 1.000 | 0.574 | 1.000 | 0.451 | 0.893 | 0.574 | 1.000 | 0.410 | 0.857 | 0.574 | 1.000 | 0.574 | 1.000 | - | - | 0.574 | 1.000 |
1040281 | HLA-B*44:02 | 9 | 16 | 7 | binary | -0.342 | 0.302 | -0.342 | 0.302 | -0.369 | 0.286 | -0.342 | 0.302 | -0.369 | 0.286 | -0.451 | 0.238 | -0.178 | 0.397 | -0.287 | 0.333 | -0.123 | 0.429 | -0.396 | 0.270 | 0.150 | 0.587 | -0.150 | 0.413 | -0.424 | 0.254 | -0.314 | 0.317 | -0.287 | 0.333 |
1040281 | HLA-B*44:03 | 9 | 16 | 2 | binary | -0.287 | 0.250 | -0.164 | 0.357 | -0.208 | 0.375 | -0.369 | 0.179 | -0.308 | 0.250 | -0.246 | 0.286 | 0.041 | 0.536 | - | - | -0.410 | 0.143 | -0.205 | 0.321 | -0.328 | 0.214 | 0.082 | 0.571 | -0.574 | 0.000 | -0.246 | 0.286 | -0.164 | 0.357 |