IEDB Analysis Resource

MHCII Weekly Benchmark results


Overall scores

Overall scores based on data sets submitted to the IED for the last at least 5 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.

Server Overall SRCC AUC
NN-align 57 52 61
NetMHCIIpan-3.1 83 85 81
Comblib matrices 10 10 10
SMM-align 55 56 55
Tepitope (Sturniolo) 18 3 34
Consensus IEDB method 65 68 62

Data set specific results

Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here

IEDB
Reference
Allele Peptide
Count
Positive
Count
Measurement
type
NN-align NetMHCIIpan-3.1 Comblib matrices SMM-align Tepitope (Sturniolo) Consensus IEDB method
SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC
 1031910   HLA-DRB1*15:01   28   23   binary   -0.462   0.152   -0.462   0.152   -   -   -0.439   0.170   -0.551   0.135   -0.462   0.152 
 1032311   HLA-DRB1*01:01   16   14   ic50   0.276   0.964   0.432   1.000   0.038   0.589   0.405   1.000   0.268   1.000   0.297   0.964 
 1032520   H2-IAb   13   6   ic50   0.720   0.810   0.670   0.857   -   -   0.621   0.738   -   -   0.742   0.810 
 1029531   HLA-DRB1*01:01   11   4   ic50   0.564   0.857   0.727   1.000   0.205   0.571   0.492   0.696   -0.009   0.571   0.764   0.929 
 1034502   HLA-DRB1*03:01   21   3   ic50   0.419   0.759   0.595   0.907   -   -   0.552   0.870   0.142   0.611   0.313   0.796 
 1034502   HLA-DRB1*08:02   21   5   ic50   0.587   1.000   0.717   0.900   -   -   0.621   0.912   0.321   0.688   0.691   0.950 
 1034502   HLA-DRB1*11:01   21   5   ic50   0.619   0.825   0.708   0.912   -   -   0.532   0.863   0.301   0.800   0.508   0.863 
 1034502   HLA-DRB1*15:01   21   4   ic50   0.680   0.882   0.764   0.853   -   -   0.697   0.794   0.596   0.882   0.823   0.882 
 1034502   HLA-DRB1*15:02   21   2   ic50   -   -   0.728   0.711   -   -   -   -   0.580   0.605   0.581   0.526