IEDB Analysis Resource

MHCII Weekly Benchmark results


Overall scores

Overall scores based on data sets submitted to the IEDB within a single week. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.

Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.


Server Overall SRCC AUC
Comblib matrices 0 0 0
Consensus IEDB method 88 88 89
NN-align 69 60 78
NN-align 2.3 - - -
NetMHCIIpan-3.1 41 39 44
NetMHCIIpan-3.2 - - -
NetMHCIIpan-4.0 BA - - -
NetMHCIIpan-4.0 EL - - -
NetMHCIIpan-4.1 BA - - -
NetMHCIIpan-4.1 EL - - -
NetMHCIIpan-4.2 BA - - -
NetMHCIIpan-4.2 EL - - -
NetMHCIIpan-4.3 BA - - -
NetMHCIIpan-4.3 EL - - -
SMM-align 63 71 54
Tepitope (Sturniolo) 7 7 7

Data set specific results

Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here.

IEDB
Reference		 Allele Peptide
Count		 Positive
Count		 Measurement
type		 Comblib matrices Consensus IEDB method NN-align NN-align 2.3 NetMHCIIpan-3.1 NetMHCIIpan-3.2 NetMHCIIpan-4.0 BA NetMHCIIpan-4.0 EL NetMHCIIpan-4.1 BA NetMHCIIpan-4.1 EL NetMHCIIpan-4.2 BA NetMHCIIpan-4.2 EL NetMHCIIpan-4.3 BA NetMHCIIpan-4.3 EL SMM-align Tepitope (Sturniolo)
SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC
 1036599   HLA-DQA1*05:01/DQB1*02:01   198   121   ic50   0.491   0.743   0.789   0.893   0.795   0.899   -   -   0.757   0.862   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   0.772   0.874   -   - 
 1036599   HLA-DRB1*01:01   34   20   ic50   0.685   0.868   0.846   0.936   0.805   0.932   -   -   0.834   0.968   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   0.832   0.925   0.706   0.914 
 1036599   HLA-DRB1*04:01   51   19   ic50   -   -   0.722   0.924   0.692   0.903   -   -   0.685   0.901   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   0.721   0.905   0.654   0.890 
 1036599   HLA-DRB1*15:01   35   23   ic50   -   -   0.854   0.989   0.842   0.989   -   -   0.776   0.957   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   0.920   0.971   0.720   0.926